盧海彬

　　 　　

一、基本信息

盧海彬，男，1981年04月生，河南新鄉(xiāng)人，西北農(nóng)林科技大學(xué)副教授。2003年獲得河南農(nóng)業(yè)大學(xué)生物技術(shù)專(zhuān)業(yè)學(xué)士學(xué)位；2010年獲得北京大學(xué)理學(xué)博士學(xué)位。

二、學(xué)習(xí)工作經(jīng)歷

學(xué)習(xí)經(jīng)歷：

2004-2010  北京大學(xué)和北京生命科學(xué)研究所

1999-2003  河南農(nóng)業(yè)大學(xué)

工作經(jīng)歷：

2016-至今      副教授        西北農(nóng)林科技大學(xué)

2015/01-02     訪(fǎng)問(wèn)學(xué)者      西班牙國(guó)家生物技術(shù)中心

2013-2015      博士后        西班牙農(nóng)業(yè)基因組研究中心

2011-2013      博士后        德國(guó)馬普植物育種研究所

2010-2011     研究助理       中國(guó)農(nóng)業(yè)科學(xué)院植物保護(hù)研

三、研究方向

利用分子生物學(xué)、細(xì)胞生物學(xué)、遺傳學(xué)和生物信息學(xué)等技術(shù)研究植物根部與病原菌相互作用的分子機(jī)制、馬鈴薯青枯病的抗性機(jī)制、植物免疫與植物生長(zhǎng)的交叉信號(hào)。

1.植物根部與病原菌相互作用的分子機(jī)制：青枯病菌和丁香假單胞菌都可以造成植物根部結(jié)構(gòu)的變化（如下圖，抑制主根生長(zhǎng)、側(cè)根形成、根尖細(xì)胞死亡等）。這種表型的變化促進(jìn)病原菌進(jìn)入植物體內(nèi)。我們以此為模型研究植物根部與病原菌的相互作用包括：病原菌如何改變根部結(jié)構(gòu)，植物如何來(lái)防止根部結(jié)構(gòu)的變化。

2.馬鈴薯青枯病抗性機(jī)制：青枯病菌通過(guò)根部侵入馬鈴薯，造成植株的枯萎死亡，導(dǎo)致馬鈴薯絕收（如下圖中Desiree發(fā)病， O和P不發(fā)病）。此外，青枯病菌還可以侵染如番茄、煙草和苜蓿等其他重要經(jīng)濟(jì)作物和園藝植物。研究植物青枯病抗病分子機(jī)制對(duì)培育作物新品種，對(duì)保護(hù)生態(tài)環(huán)境和國(guó)家糧食安全具有重要意義。

3.植物抗病性與植物生長(zhǎng)之間拮抗作用的分子機(jī)制：植物抗病性的增加會(huì)抑制植物的生長(zhǎng)發(fā)育，進(jìn)而降低作物的產(chǎn)量。研究它們之間的“交叉對(duì)話(huà)”可以促使培育高產(chǎn)、高抗病性的作物新品種。

四、本科教學(xué)課程

本科生教學(xué)課程包括《作物基因工程》和《設(shè)計(jì)生命：基因組編輯技術(shù)的過(guò)去、現(xiàn)在和未來(lái)》等。

五、承擔(dān)科研項(xiàng)目情況

主持國(guó)家自然科學(xué)基金、陜西省科技計(jì)劃、寧夏農(nóng)林科學(xué)院對(duì)合作項(xiàng)目和寧夏重點(diǎn)研發(fā)計(jì)劃等項(xiàng)目

六、學(xué)術(shù)成果

Xiang Wang, Qichang Gong, Shengyang Cheng, Ning Qin, Tao Cao, Yue Chen, Dongdong Wang, Marc Valls, Nuria S. Coll, Qin Chen, Cuizhu Zhao, and Haibin Lu*. Cytokinin plays a multifaceted role in Ralstonia solanacearum-triggered plant disease development. 2024. Molecular Plant Pathology. e70045.

Yang Niu, Shouyang Fu, Gong Chen, Huijuan Wang, Yisa Wang, JinXue Hu Xin Jin, Mancang Zhang, Mingxia Lu, Yizhe He, Dongdong Wang, Yue Chen, Yong Zhang，Núria. Coll6, Marc Valls, Cuizhu Zhao*, Qin Chen* and Haibin Lu*. Different epitopes of Ralstonia solanacearum effector RipAW are respectively recognized by two Nicotiana species and trigger immune responses. 2021. Molecular Plant Pathology. doi.org/10.1111/mpp.13153.

Li, W., Chen, Y., Ye, MH., Lu, H., Wang, DD and Chen, Q. 2020. Evolutionary History of the C-repeat binding factor/dehydration-responsive element-binding 1 (CBF/DREEB1) protein family in 43 plant species and characterization of CBF/DREB1 proteins in Solanum tuberosum. BMC Evolutionary Biology. 20: 142

Qin, N., Zhang, RZ., Zhang, MC., Niu, Y., Fu, SY., Wang, YS., Wang, DD., Chen, Y., Zhao, CZ., Chen, Q and Lu, H. 2020. Global profiling in Arabidopsis root upon Ralstonia solanacearum infection. Genes. 11. 1078

Wang, H., Hu, J., Lu, Y., Zhang, M., Qin, N., Zhang, R., He, Y., Wang, D., Chen, Y., Zhao, C., Coll, S., Valls, M., Chen, Q and Lu, H. 2019. A quick and efficient hydroponic potato infection method for evaluating potato resistance and Ralstonia solanacearum virulence. Plant Methods. 15：145. DOI. 10.1186/s13007-019-0530-9. (Corresponding author)

Zhao, C., Wang, H., Lu, Y., Hu, J., Qu, L., Li, Z., Wang, D., He, Y., Valls, M., Coll, NS., Chen Q and Lu, H. 2019.Deep sequencing reveals early reprogramming of arabidopsis root transcriptomes upon Ralstonia solanacearum infection. MPMI.32: 813-827. (Corresponding author)

Lu, H., Lema, S., Planas-Marques, M., Alonso-Diaz, A., Valls, M. and Coll N. 2018 Type three secretion-dependent and –independent phenotypes caused by Ralstonia solanacearum in Arabidopsis root. MPMI. 31:175-184.

Zuluaga, A. P*., Sole, M*., Lu, H*., Gongora-Castillo, E., Coll, N. S., Buell, C. R. and Valls, M. 2015. Transcriptome response to Ralstonia solanacearum infection in the roots of the wild potato Solanum commersonii. BMC Genomics. 16:246 (* These authors contributed equally to this work).

Lu, H., Chandrasekar, B., Oeljeklaus, J., Misas-Villamil, J., Wang, Z., Shindo, T., Bogyo, M., Kaiser, M. and Van der Hoorn, RAL. 2015. Subfamily-specific fluorescent probes for Cys proteases display dynamic protease activities during seed germination. Plant Physiology.168:1462-1475.

Lu, H., Wang, Z., Shabab, M., Verhelst, S. H., Kaschani, F., Kaiser M., Bogyo, M. and Van der Hoorn, R.A.L. 2013. A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type Ⅲ effector protease AvrPphB. Chemistry & Biology. 20:168-176 (Highlighted)

Li, W., Ahn, I., Ning, Y., Park, C., Zeng, L., Whitehill, J., Lu, H., Zhao, Q., Ding, B., Xie Q., Zhou J., Dai, L. and Wang, G.. 2012. The U-Box/ARM E3 ligase PUB13 regulates cell death, defense, and flowering time in Arabidopsis. Plant Physiology. 159:239-250.

Zhang, J*., Lu, H*., Li, X., Li, Y., Cui, H., Wen, C., Tang, X., Su Z. And Zhou, J. 2010. Effector-triggered and Pathogen-associated molecular pattern-triggered immunity differentially contribute to basal resistance to Pseudomonas syringae. Molecular Plant-Microbe Interactions. 23:940-948.

Lu, H”, Feng, N., and Zou, Y. 2010. Overexpression AHL20 negatively regulates defense in Arabidopsis. Journal of Integrative Plant Biology. 52:801-808

Peng, Z., Zhou, X., Li, L., Yu, X., Li, H., Jiang, Z., Cao, G., Bai, M., Wang, X., Jiang, C., Lu,H., Hou, X., Qu, L., Wang, Z., Zuo, J., Fu, X., Su, Z., Li, S. and Guo, H. 2009. Arabidopsis hormone database: a comprehensive genetic and phenotypic information database for plant hormone research in Arabidopsis. Nucleic Acids Research. 37: D975-D982.

七、聯(lián)系方式

通訊地址：陜西楊凌邰城路3號(hào)

郵編：712100

E-mail：luhaibin011@163.com